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CEM Corporation cell lines ccrf-cem
Cell Lines Ccrf Cem, supplied by CEM Corporation, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/cell+lines+ccrf-cem/t+all+cell+lines/pm40658887-146-11-15
Average 90 stars, based on 1 article reviews
cell lines ccrf-cem - by Bioz Stars, 2026-09
90/100 stars

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Related Articles

Activation Assay:

Article Title: Anti-NKG2A antibodies and compositions
Article Snippet: Materials and Methods The expression of endogenous HLA-E in six different cell lines (HT-29, CCRF-CEM, A253, Detroit 562, CAL-120, and FaDu) was investigated by flow cytometry.

Article Title: Impact of Plastic-Related Compounds on P-Glycoprotein and Breast Cancer Resistance Protein In Vitro.
Article Snippet: Compounds 3 and 4 displayed an IC50 value of 54.73 ± 1.42 and 31.86 ± 3.35 μM, respectively, on CEM/ADR5000 and CCRF-CEM cell lines.

Article Title: Multispecific polypeptide constructs having constrained CD3 binding and related methods and uses
Article Snippet: To assess T cell activation, suspension cells from T cell cytotoxicity assays above, involving culture of T cells with B7H3 positive (A375) or B7H3 negative cell lines (CCRF-CEM) in the presence of an exemplary B7H3-targeted constrained CD3 engaging constructs, were collected.

Article Title: Lewis base-catalyzed synthesis of highly functionalized spirooxindole-pyranopyrazoles and their in vitro anticancer studies
Article Snippet: Herein, the one-step, multi-component reaction (MCR) of a series of spirooxindole-pyranopyrazole derivatives (5a-g), via a Knoevenagel condensation and Michael addition cascade, under mild and green reaction conditions, is reported.. The newly synthesized derivatives were screened for in vitro anti-cancer activity against 60 human cancer cell lines at the National Cancer Institute (NCI), USA.. We found that compounds 5c, 5d, and 5g showed good activity against the HOP-92 (lung cancer), UO-31 (renal cancer), KM-12, SW-620 (colon cancer), and HS578T (breast cancer) cell lines.

Article Title: An Integrated Method to Evaluate the Treatment Efficacy and Immunogenicity of B-Cell Acute Lymphoblastic Leukemia Therapeutic Enzyme Formulations.
Article Snippet: [41] Additionally, differences in basal (untreated) ASNS protein expression between those cell lines (CCRF-SB > CCRF-CEM > RS4;11) have been measured, with inversely proportional ASNase sensitivity.

Article Title: Identification of Potential Biomarkers and Pathways in Acute Myeloid Leukemia: Correlation Between the Calcineurin Signaling Pathway and Vascular Brittleness in Acute Myeloid Leukemia.
Article Snippet: Objective: In this study, clinical bioinformatics analysis was used to identify potential biomarkers of acute myeloid leukemia (AML) occurrence and development, drug resistance, and poor prognosis to provide a theoretical basis for the treatment of AML.. Methods: On the basis of the TCGA, GEO, and GTEx databases, an AML secondary database was established, and differential expression analysis and WGCNA were carried out to identify genes related to the prognosis of AML patients.. Survival analysis was carried out for internal verification of key genes, and GEO data were used for external verification to obtain core genes related to prognosis.

Article Title: Treatment of cancers using PI3 kinase isoform modulators
Article Snippet: Various human and marine ALL cell lines including PTEN deficient cell lines (Loucy, Molt-4 luc, CCRF-CEM, p12 Ichikawa, Karpas-45 and CEM/C2) and PTEN wildtype cell lines (Molt-13 and Molt-16) were treated with Compound 292, and inhibition of growth was assessed.

Article Title: FBXO21 mediated degradation of p85α regulates proliferation and survival of acute myeloid leukemia.
Article Snippet: D Western blot probing for FBXO21 in two independent HBM samples compared to patient-derived AML (MOLM-13, THP-1, HL-60, and KASUMI-1) and ALL (MOLT-4, CCRF-CEM, and RS4(11)) cell lines. (ns non-significant, *p ≤ 0.05, ****p ≤ 0.0001).

Suspension:

Article Title: Anti-NKG2A antibodies and compositions
Article Snippet: Materials and Methods The expression of endogenous HLA-E in six different cell lines (HT-29, CCRF-CEM, A253, Detroit 562, CAL-120, and FaDu) was investigated by flow cytometry.

Article Title: Impact of Plastic-Related Compounds on P-Glycoprotein and Breast Cancer Resistance Protein In Vitro.
Article Snippet: Compounds 3 and 4 displayed an IC50 value of 54.73 ± 1.42 and 31.86 ± 3.35 μM, respectively, on CEM/ADR5000 and CCRF-CEM cell lines.

Article Title: Multispecific polypeptide constructs having constrained CD3 binding and related methods and uses
Article Snippet: To assess T cell activation, suspension cells from T cell cytotoxicity assays above, involving culture of T cells with B7H3 positive (A375) or B7H3 negative cell lines (CCRF-CEM) in the presence of an exemplary B7H3-targeted constrained CD3 engaging constructs, were collected.

Article Title: Lewis base-catalyzed synthesis of highly functionalized spirooxindole-pyranopyrazoles and their in vitro anticancer studies
Article Snippet: Herein, the one-step, multi-component reaction (MCR) of a series of spirooxindole-pyranopyrazole derivatives (5a-g), via a Knoevenagel condensation and Michael addition cascade, under mild and green reaction conditions, is reported.. The newly synthesized derivatives were screened for in vitro anti-cancer activity against 60 human cancer cell lines at the National Cancer Institute (NCI), USA.. We found that compounds 5c, 5d, and 5g showed good activity against the HOP-92 (lung cancer), UO-31 (renal cancer), KM-12, SW-620 (colon cancer), and HS578T (breast cancer) cell lines.

Article Title: An Integrated Method to Evaluate the Treatment Efficacy and Immunogenicity of B-Cell Acute Lymphoblastic Leukemia Therapeutic Enzyme Formulations.
Article Snippet: [41] Additionally, differences in basal (untreated) ASNS protein expression between those cell lines (CCRF-SB > CCRF-CEM > RS4;11) have been measured, with inversely proportional ASNase sensitivity.

Article Title: Identification of Potential Biomarkers and Pathways in Acute Myeloid Leukemia: Correlation Between the Calcineurin Signaling Pathway and Vascular Brittleness in Acute Myeloid Leukemia.
Article Snippet: Objective: In this study, clinical bioinformatics analysis was used to identify potential biomarkers of acute myeloid leukemia (AML) occurrence and development, drug resistance, and poor prognosis to provide a theoretical basis for the treatment of AML.. Methods: On the basis of the TCGA, GEO, and GTEx databases, an AML secondary database was established, and differential expression analysis and WGCNA were carried out to identify genes related to the prognosis of AML patients.. Survival analysis was carried out for internal verification of key genes, and GEO data were used for external verification to obtain core genes related to prognosis.

Article Title: Treatment of cancers using PI3 kinase isoform modulators
Article Snippet: Various human and marine ALL cell lines including PTEN deficient cell lines (Loucy, Molt-4 luc, CCRF-CEM, p12 Ichikawa, Karpas-45 and CEM/C2) and PTEN wildtype cell lines (Molt-13 and Molt-16) were treated with Compound 292, and inhibition of growth was assessed.

Article Title: FBXO21 mediated degradation of p85α regulates proliferation and survival of acute myeloid leukemia.
Article Snippet: D Western blot probing for FBXO21 in two independent HBM samples compared to patient-derived AML (MOLM-13, THP-1, HL-60, and KASUMI-1) and ALL (MOLT-4, CCRF-CEM, and RS4(11)) cell lines. (ns non-significant, *p ≤ 0.05, ****p ≤ 0.0001).

Construct:

Article Title: Anti-NKG2A antibodies and compositions
Article Snippet: Materials and Methods The expression of endogenous HLA-E in six different cell lines (HT-29, CCRF-CEM, A253, Detroit 562, CAL-120, and FaDu) was investigated by flow cytometry.

Article Title: Impact of Plastic-Related Compounds on P-Glycoprotein and Breast Cancer Resistance Protein In Vitro.
Article Snippet: Compounds 3 and 4 displayed an IC50 value of 54.73 ± 1.42 and 31.86 ± 3.35 μM, respectively, on CEM/ADR5000 and CCRF-CEM cell lines.

Article Title: Multispecific polypeptide constructs having constrained CD3 binding and related methods and uses
Article Snippet: To assess T cell activation, suspension cells from T cell cytotoxicity assays above, involving culture of T cells with B7H3 positive (A375) or B7H3 negative cell lines (CCRF-CEM) in the presence of an exemplary B7H3-targeted constrained CD3 engaging constructs, were collected.

Article Title: Lewis base-catalyzed synthesis of highly functionalized spirooxindole-pyranopyrazoles and their in vitro anticancer studies
Article Snippet: Herein, the one-step, multi-component reaction (MCR) of a series of spirooxindole-pyranopyrazole derivatives (5a-g), via a Knoevenagel condensation and Michael addition cascade, under mild and green reaction conditions, is reported.. The newly synthesized derivatives were screened for in vitro anti-cancer activity against 60 human cancer cell lines at the National Cancer Institute (NCI), USA.. We found that compounds 5c, 5d, and 5g showed good activity against the HOP-92 (lung cancer), UO-31 (renal cancer), KM-12, SW-620 (colon cancer), and HS578T (breast cancer) cell lines.

Article Title: An Integrated Method to Evaluate the Treatment Efficacy and Immunogenicity of B-Cell Acute Lymphoblastic Leukemia Therapeutic Enzyme Formulations.
Article Snippet: [41] Additionally, differences in basal (untreated) ASNS protein expression between those cell lines (CCRF-SB > CCRF-CEM > RS4;11) have been measured, with inversely proportional ASNase sensitivity.

Article Title: Identification of Potential Biomarkers and Pathways in Acute Myeloid Leukemia: Correlation Between the Calcineurin Signaling Pathway and Vascular Brittleness in Acute Myeloid Leukemia.
Article Snippet: Objective: In this study, clinical bioinformatics analysis was used to identify potential biomarkers of acute myeloid leukemia (AML) occurrence and development, drug resistance, and poor prognosis to provide a theoretical basis for the treatment of AML.. Methods: On the basis of the TCGA, GEO, and GTEx databases, an AML secondary database was established, and differential expression analysis and WGCNA were carried out to identify genes related to the prognosis of AML patients.. Survival analysis was carried out for internal verification of key genes, and GEO data were used for external verification to obtain core genes related to prognosis.

Article Title: Treatment of cancers using PI3 kinase isoform modulators
Article Snippet: Various human and marine ALL cell lines including PTEN deficient cell lines (Loucy, Molt-4 luc, CCRF-CEM, p12 Ichikawa, Karpas-45 and CEM/C2) and PTEN wildtype cell lines (Molt-13 and Molt-16) were treated with Compound 292, and inhibition of growth was assessed.

Article Title: FBXO21 mediated degradation of p85α regulates proliferation and survival of acute myeloid leukemia.
Article Snippet: D Western blot probing for FBXO21 in two independent HBM samples compared to patient-derived AML (MOLM-13, THP-1, HL-60, and KASUMI-1) and ALL (MOLT-4, CCRF-CEM, and RS4(11)) cell lines. (ns non-significant, *p ≤ 0.05, ****p ≤ 0.0001).

Expressing:

Article Title: Anti-NKG2A antibodies and compositions
Article Snippet: Materials and Methods The expression of endogenous HLA-E in six different cell lines (HT-29, CCRF-CEM, A253, Detroit 562, CAL-120, and FaDu) was investigated by flow cytometry.

Article Title: Impact of Plastic-Related Compounds on P-Glycoprotein and Breast Cancer Resistance Protein In Vitro.
Article Snippet: Compounds 3 and 4 displayed an IC50 value of 54.73 ± 1.42 and 31.86 ± 3.35 μM, respectively, on CEM/ADR5000 and CCRF-CEM cell lines.

Article Title: Multispecific polypeptide constructs having constrained CD3 binding and related methods and uses
Article Snippet: To assess T cell activation, suspension cells from T cell cytotoxicity assays above, involving culture of T cells with B7H3 positive (A375) or B7H3 negative cell lines (CCRF-CEM) in the presence of an exemplary B7H3-targeted constrained CD3 engaging constructs, were collected.

Article Title: Lewis base-catalyzed synthesis of highly functionalized spirooxindole-pyranopyrazoles and their in vitro anticancer studies
Article Snippet: Herein, the one-step, multi-component reaction (MCR) of a series of spirooxindole-pyranopyrazole derivatives (5a-g), via a Knoevenagel condensation and Michael addition cascade, under mild and green reaction conditions, is reported.. The newly synthesized derivatives were screened for in vitro anti-cancer activity against 60 human cancer cell lines at the National Cancer Institute (NCI), USA.. We found that compounds 5c, 5d, and 5g showed good activity against the HOP-92 (lung cancer), UO-31 (renal cancer), KM-12, SW-620 (colon cancer), and HS578T (breast cancer) cell lines.

Article Title: An Integrated Method to Evaluate the Treatment Efficacy and Immunogenicity of B-Cell Acute Lymphoblastic Leukemia Therapeutic Enzyme Formulations.
Article Snippet: [41] Additionally, differences in basal (untreated) ASNS protein expression between those cell lines (CCRF-SB > CCRF-CEM > RS4;11) have been measured, with inversely proportional ASNase sensitivity.

Article Title: Identification of Potential Biomarkers and Pathways in Acute Myeloid Leukemia: Correlation Between the Calcineurin Signaling Pathway and Vascular Brittleness in Acute Myeloid Leukemia.
Article Snippet: Objective: In this study, clinical bioinformatics analysis was used to identify potential biomarkers of acute myeloid leukemia (AML) occurrence and development, drug resistance, and poor prognosis to provide a theoretical basis for the treatment of AML.. Methods: On the basis of the TCGA, GEO, and GTEx databases, an AML secondary database was established, and differential expression analysis and WGCNA were carried out to identify genes related to the prognosis of AML patients.. Survival analysis was carried out for internal verification of key genes, and GEO data were used for external verification to obtain core genes related to prognosis.

Article Title: Treatment of cancers using PI3 kinase isoform modulators
Article Snippet: Various human and marine ALL cell lines including PTEN deficient cell lines (Loucy, Molt-4 luc, CCRF-CEM, p12 Ichikawa, Karpas-45 and CEM/C2) and PTEN wildtype cell lines (Molt-13 and Molt-16) were treated with Compound 292, and inhibition of growth was assessed.

Article Title: FBXO21 mediated degradation of p85α regulates proliferation and survival of acute myeloid leukemia.
Article Snippet: D Western blot probing for FBXO21 in two independent HBM samples compared to patient-derived AML (MOLM-13, THP-1, HL-60, and KASUMI-1) and ALL (MOLT-4, CCRF-CEM, and RS4(11)) cell lines. (ns non-significant, *p ≤ 0.05, ****p ≤ 0.0001).

Flow Cytometry:

Article Title: Anti-NKG2A antibodies and compositions
Article Snippet: Materials and Methods The expression of endogenous HLA-E in six different cell lines (HT-29, CCRF-CEM, A253, Detroit 562, CAL-120, and FaDu) was investigated by flow cytometry.

Article Title: Impact of Plastic-Related Compounds on P-Glycoprotein and Breast Cancer Resistance Protein In Vitro.
Article Snippet: Compounds 3 and 4 displayed an IC50 value of 54.73 ± 1.42 and 31.86 ± 3.35 μM, respectively, on CEM/ADR5000 and CCRF-CEM cell lines.

Article Title: Multispecific polypeptide constructs having constrained CD3 binding and related methods and uses
Article Snippet: To assess T cell activation, suspension cells from T cell cytotoxicity assays above, involving culture of T cells with B7H3 positive (A375) or B7H3 negative cell lines (CCRF-CEM) in the presence of an exemplary B7H3-targeted constrained CD3 engaging constructs, were collected.

Article Title: Lewis base-catalyzed synthesis of highly functionalized spirooxindole-pyranopyrazoles and their in vitro anticancer studies
Article Snippet: Herein, the one-step, multi-component reaction (MCR) of a series of spirooxindole-pyranopyrazole derivatives (5a-g), via a Knoevenagel condensation and Michael addition cascade, under mild and green reaction conditions, is reported.. The newly synthesized derivatives were screened for in vitro anti-cancer activity against 60 human cancer cell lines at the National Cancer Institute (NCI), USA.. We found that compounds 5c, 5d, and 5g showed good activity against the HOP-92 (lung cancer), UO-31 (renal cancer), KM-12, SW-620 (colon cancer), and HS578T (breast cancer) cell lines.

Article Title: An Integrated Method to Evaluate the Treatment Efficacy and Immunogenicity of B-Cell Acute Lymphoblastic Leukemia Therapeutic Enzyme Formulations.
Article Snippet: [41] Additionally, differences in basal (untreated) ASNS protein expression between those cell lines (CCRF-SB > CCRF-CEM > RS4;11) have been measured, with inversely proportional ASNase sensitivity.

Article Title: Identification of Potential Biomarkers and Pathways in Acute Myeloid Leukemia: Correlation Between the Calcineurin Signaling Pathway and Vascular Brittleness in Acute Myeloid Leukemia.
Article Snippet: Objective: In this study, clinical bioinformatics analysis was used to identify potential biomarkers of acute myeloid leukemia (AML) occurrence and development, drug resistance, and poor prognosis to provide a theoretical basis for the treatment of AML.. Methods: On the basis of the TCGA, GEO, and GTEx databases, an AML secondary database was established, and differential expression analysis and WGCNA were carried out to identify genes related to the prognosis of AML patients.. Survival analysis was carried out for internal verification of key genes, and GEO data were used for external verification to obtain core genes related to prognosis.

Article Title: Treatment of cancers using PI3 kinase isoform modulators
Article Snippet: Various human and marine ALL cell lines including PTEN deficient cell lines (Loucy, Molt-4 luc, CCRF-CEM, p12 Ichikawa, Karpas-45 and CEM/C2) and PTEN wildtype cell lines (Molt-13 and Molt-16) were treated with Compound 292, and inhibition of growth was assessed.

Article Title: FBXO21 mediated degradation of p85α regulates proliferation and survival of acute myeloid leukemia.
Article Snippet: D Western blot probing for FBXO21 in two independent HBM samples compared to patient-derived AML (MOLM-13, THP-1, HL-60, and KASUMI-1) and ALL (MOLT-4, CCRF-CEM, and RS4(11)) cell lines. (ns non-significant, *p ≤ 0.05, ****p ≤ 0.0001).

Inhibition:

Article Title: Anti-NKG2A antibodies and compositions
Article Snippet: Materials and Methods The expression of endogenous HLA-E in six different cell lines (HT-29, CCRF-CEM, A253, Detroit 562, CAL-120, and FaDu) was investigated by flow cytometry.

Article Title: Impact of Plastic-Related Compounds on P-Glycoprotein and Breast Cancer Resistance Protein In Vitro.
Article Snippet: Compounds 3 and 4 displayed an IC50 value of 54.73 ± 1.42 and 31.86 ± 3.35 μM, respectively, on CEM/ADR5000 and CCRF-CEM cell lines.

Article Title: Multispecific polypeptide constructs having constrained CD3 binding and related methods and uses
Article Snippet: To assess T cell activation, suspension cells from T cell cytotoxicity assays above, involving culture of T cells with B7H3 positive (A375) or B7H3 negative cell lines (CCRF-CEM) in the presence of an exemplary B7H3-targeted constrained CD3 engaging constructs, were collected.

Article Title: Lewis base-catalyzed synthesis of highly functionalized spirooxindole-pyranopyrazoles and their in vitro anticancer studies
Article Snippet: Herein, the one-step, multi-component reaction (MCR) of a series of spirooxindole-pyranopyrazole derivatives (5a-g), via a Knoevenagel condensation and Michael addition cascade, under mild and green reaction conditions, is reported.. The newly synthesized derivatives were screened for in vitro anti-cancer activity against 60 human cancer cell lines at the National Cancer Institute (NCI), USA.. We found that compounds 5c, 5d, and 5g showed good activity against the HOP-92 (lung cancer), UO-31 (renal cancer), KM-12, SW-620 (colon cancer), and HS578T (breast cancer) cell lines.

Article Title: An Integrated Method to Evaluate the Treatment Efficacy and Immunogenicity of B-Cell Acute Lymphoblastic Leukemia Therapeutic Enzyme Formulations.
Article Snippet: [41] Additionally, differences in basal (untreated) ASNS protein expression between those cell lines (CCRF-SB > CCRF-CEM > RS4;11) have been measured, with inversely proportional ASNase sensitivity.

Article Title: Identification of Potential Biomarkers and Pathways in Acute Myeloid Leukemia: Correlation Between the Calcineurin Signaling Pathway and Vascular Brittleness in Acute Myeloid Leukemia.
Article Snippet: Objective: In this study, clinical bioinformatics analysis was used to identify potential biomarkers of acute myeloid leukemia (AML) occurrence and development, drug resistance, and poor prognosis to provide a theoretical basis for the treatment of AML.. Methods: On the basis of the TCGA, GEO, and GTEx databases, an AML secondary database was established, and differential expression analysis and WGCNA were carried out to identify genes related to the prognosis of AML patients.. Survival analysis was carried out for internal verification of key genes, and GEO data were used for external verification to obtain core genes related to prognosis.

Article Title: Treatment of cancers using PI3 kinase isoform modulators
Article Snippet: Various human and marine ALL cell lines including PTEN deficient cell lines (Loucy, Molt-4 luc, CCRF-CEM, p12 Ichikawa, Karpas-45 and CEM/C2) and PTEN wildtype cell lines (Molt-13 and Molt-16) were treated with Compound 292, and inhibition of growth was assessed.

Article Title: FBXO21 mediated degradation of p85α regulates proliferation and survival of acute myeloid leukemia.
Article Snippet: D Western blot probing for FBXO21 in two independent HBM samples compared to patient-derived AML (MOLM-13, THP-1, HL-60, and KASUMI-1) and ALL (MOLT-4, CCRF-CEM, and RS4(11)) cell lines. (ns non-significant, *p ≤ 0.05, ****p ≤ 0.0001).



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